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  • 17650-98-5 br Our analyses included haplotype association

    2020-08-14


    Our analyses included haplotype association of pairwise SNPs, rs3020314 and rs1514348 with breast cancer risk. The r2 between rs3020214 and rs1514348 in the present study was 0.008. The fre-quencies in the haplotype block were comparable between the case and control groups, and we found no evidence for the association of breast cancer risk and genetic variation in haplotypes of pairwise SNPs of ESR1 gene. The result of the haplotype analysis is in line with HapMap
    A.T. Gebreslasie, et al.
    data of YRI population (Yoruba in Ibadan, Nigeria) where r2is only 0.009. Thus, in both populations the r2 is very low, indicating a very weak link between these two SNPs.
    In conclusion, a significant association of breast cancer was ob-served with the CT 17650-98-5 of SNP-rs3020314 compared to the wild type CC genotype among Sudanese women; this is similar to that of Asian and Caucasian populations. The heterozygous genotype CT of SNPrs1514348 showed a protective or reduced breast cancer risk, which disagrees with the previous published data. These inconsistent findings might be attributed to geographic and ethnic characteristics of the population being studied, as there are considerable variations in the distribution of the genotypes in various populations.
    Addressing the limitations of this study, we refer to its small sample size and lack of patients' follow-up data that could add information on relation of genotype to response to therapy, or disease outcome. However, the findings of this study are expected to serve as a basis for future studies.
    Our data suggest that the ESR1 polymorphism rs3020314 might contribute to increased breast cancer risk, whereas rs1514348 could relate to decreased risk in Sudanese women. However, these findings need to be tested with further studies analyzing a larger number of Sudanese women in a population-based approach.
    Acknowledgements
    We thank all participants; our thanks extend to the staff of National Cancer Institute (NCI-UG), University of Gezira, Sudan. This work was supported by a grant from the National Board for Higher Education of the State of Eritrea.
    Conflicts of interest
    The authors declare that they have no competing interests.
    References
    Anderson, E., 2002. The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res. 4 (5), 197–201.
    Atoum, M.F., Alzoughool, F., 2017. Reduction in breast cancer susceptibility due to XbaI gene polymorphism of alpha estrogen receptor gene in Jordanians. Breast Cancer 9, 45–49.
    Gallagher CJ, Langefeld CD, Gordon CJ, Campbell JK, Mychaleckyj JC, Bryer-Ash M, et al. Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2007;56(8):2135–41.
    Mavaddat, N., Dunning, A.M., Ponder, B.A., Easton, D.F., Pharoah, P.D., 2009. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Cancer Epidemiol. Biomark. Prev. 18 (1), 255–259 (A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology).
    Milne RL, Gaudet MM, Spurdle AB, Fasching PA, Couch FJ, Benitez J, et al. Assessing interactions between the associations of common genetic susceptibility variants, re-productive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Res.. 2010;12(6):R110.
    Quan L, Hong CC, Zirpoli G, Roberts MR, Khoury T, Sucheston-Campbell LE, et al. Variants of estrogen-related genes and breast cancer risk in European and African American women. Endocr. Relat. Cancer. 2014;21(6):853–64.
    Vallejos CS, Gomez HL, Cruz WR, Pinto JA, Dyer RR, Velarde R, et al. Breast cancer classification according to immunohistochemistry markers: subtypes and association with clinicopathologic variables in a Peruvian hospital database. Clin. Breast Cancer. 2010;10(4):294–300.
    Contents lists available at ScienceDirect
    Pathology - Research and Practice
    journal homepage: www.elsevier.com/locate/prp
    Association of hCG and LHCGR expression patterns with clinicopathological T parameters in ovarian cancer
    Yuanyuan Zhonga, Yingying Wangb, Jianfei Huangc, Xiangyu Xua, Weidong Pana, Sainan Gaoa, Yuquan Zhanga, , Min Sua, a Department of Obstetrics and Gynecology; Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China
    b Laboratory of Immunology, Nantong University, China; Nantong University, Nantong, Jiangsu 226001, China
    c Department of Pathology; Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China