br All authors are employed by the American
All authors are employed by the American Cancer Society, which receives grants from private and corporate foundations, including foundations associated with companies in the health sector for research outside of the submitted work. The authors are not funded by or key personnel for any of these Phosphatase Inhibitor Cocktail grants and their salary is solely funded through American Cancer Society funds. No other financial disclosures were reported.
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Changes in eudaimonic well-being and the conserved transcriptional response to adversity in younger breast cancer survivors
Chloe C. Boylea, , Steve W. Colea,b,c, Janine M. Dutcherd, Naomi I. Eisenbergere, Julienne E. Bowera,b,e a Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, United States b Department of Psychiatry and Biobehavioral Sciences, UCLA, United States c Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine d Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, United States e Department of Psychology, University of California, Los Angeles, CA, United States
Background: The conserved transcriptional response to adversity (CTRA), characterized by increased expression of proinflammatory genes and decreased expression of antiviral and antibody-related genes, is upregulated in the context of chronic adversity and distress and has been linked to cancer progression. Several studies suggest that the CTRA may also be down-regulated in association with some positive psychological states, particularly eu-daimonic well-being. However, it is not clear if the link between inter-individual differences in the CTRA and eudaimonic well-being can be extended to intra-individual change. Using a standardized mindfulness-based intervention, the current study tested whether mindfulness-related increases in eudaimonic well-being related to intra-individual reduction in the CTRA in a sample of younger breast cancer survivors.
Methods: Participants were 22 women who had been diagnosed and treated for early-stage breast cancer at or before age 50 (Mage = 46.6 years) and had no evidence of active disease. Women completed self-report ques-tionnaires and provided peripheral blood samples before and after a 6-week mindfulness meditation interven-tion. Regression analyses were used to quantify associations between the magnitude of change in eudaimonic well-being and the magnitude of change in the global CTRA score.
Results: Women reported significant increases in eudaimonic well–being and showed decreased expression of the pro-inflammatory subcomponent of the CTRA from pre- to post-intervention. The magnitude of increase in eudaimonic well-being was associated with the magnitude of decrease in the composite CTRA score, and this relationship was driven primarily by increased expression of the antiviral/antibody-related CTRA sub-component. While the intervention was also associated with reduced depressive symptoms, there was no asso-ciation between change in depressive symptoms and change in the overall CTRA composite score or either of its subcomponents.